Protein Resins
Genscript Corporation Protein A/G Magbeads MX
The GenScript Protein A/G MagBeads MX are ideal for small scale purification of antibodies from plasma serum ascites and cell culture
Genscript Corporation Protein A Resin FF
GenScript s Protein A Resin FF is an affinity chromatography media designed for easy one-step purification of classes subclasses and fragments of immunoglobulins from biological fluids and from cell culture media The recombinant protein A ligand is coupled to 4% highly cross-linked agarose The coupling is optimized to have a high binding capacity for immunoglobulins The static binding capacity of Protein A Resin FF is greater than 40 mg rabbit IgG/ ml settled resin The dynamic binding capacity will vary depending on several factors such as target antibody flow rate etc Table 1 lists the characteristics of Protein A Resin FF br br Protein A a bacterial cell wall protein isolated from i Staphylococcus aureus /i binds to mammalian IgGs mainly at their Fc region Native protein A has five IgG binding domains and many other domains with unknown functions Recombinant protein A contains five high affinity IgG binding domains with other non-essential domains removed to reduce n
Genscript Corporation Protein G Resin FF
GenScript Protein G Resin FF is an affinity chromatography medium designed for easy one-step purification of classes subclasses and fragments of immunoglobulins from biological fluids and from cell culture media
Genscript Corporation AmMag Ultra AT protein A mag
AmMag Ultra AT Protein A Magbeads are developed and optimized for antibody purification for high throughput and high volume applications and can withstand 1M alkali
Genscript Corporation Protein G Resin FF
GenScript Protein G Resin FF is an affinity chromatography medium designed for easy one-step purification of classes subclasses and fragments of immunoglobulins from biological fluids and from cell culture media
AdipoGen TAPBPL mouseFc h rec
Recombinant Protein. The extracellular domain of mouse TAPBPL aa 21-412 is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. T cells play critical roles in the adaptive immune system, protecting the human body against cancer, bacterial, viral, fungal, and parasitic infections. T cell immune response is tightly controlled by immune checkpoint proteins that negatively or positively regulate T cell response. Among the immune checkpoint proteins, the B7 family plays a key role in controlling immune responses and belongs to the immunoglobulin Ig superfamily. A number of B7 family ligands have been identified, such as B7-1 CD80, B7-2 CD86, PD-L1 B7-H1, PD-L2 B7-DC, B7-H2 inducible T cell co-stimulator ligand ICOS, B7-H3, B7-H4 B7x, B7S1, B7-H5 VISTA and B7- H6. Because of the potential clinical applications of immune checkpoint proteins, there has been intense interest in identifying additional T-cell regulators.
AdipoGen Fc humanFGL1 mouse rec
Recombinant Protein. Mouse FGL1 aa 23-314 is fused at the N-terminus to the Fc portion of human IgG1 and at the C-terminus to a His-Tag. Should activate mouse LAG-3 activity test not yet performed. Source/Host HEK 293 cells. Endotoxin <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. FGL1 Fibrinogen-like protein 1 also called Hepatocyte-derived fibrinogen-related protein 1 HFREP-1 or Hepassocin was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. A low level expression of FGL1 is also observed in the pancreas. FGL1 is a 34 kDa protein structurally similar to Angiopoietin-like factors 2, 3, 4 and 6, which regulate lipid metabolism and energy utilization.
AdipoGen POP1 human rec
Protein. Human POP1 aa 2-89 is fused at the N-terminus to a GST tag. Source E. coli. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin IL-1beta and IL-18. Members of the Nod-like receptor family NLRs, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 FCAS1, Muckle-Wells syndrome MWS and of chronic infantile neurologic cutaneous and articular syndrome CINCA. Pyrin domain-containing protein 1 POP1 interacts with the protein Asc Pycard and modulates the interaction of Asc to NLR proteins.
AdipoGen IGFLR1 hFc h rec
Protein. Human IGFLR1 aa 23-154 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.05EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to its ligand IGFL3 human Prod. No. AG-40B-0090 http//www.adipogen.com/ag-40b-0090/igfl3-human-rec.html in the subnanomolar range < 1ng /ml. Purity >95% SDS-PAGE. Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans IGFL1 to 4 and one in mice mIGFL. mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 formerly TMEM-149. Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family.
AdipoGen Progranulin rat rec
Protein. Signal peptide and rat progranulin aa 1-602 are fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >95% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
AdipoGen Contactin-6 hFc h rec
Protein. Human contactin-6 aa 1-999 is fused at the C-terminus to the Fc portion of human IgG. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. Contactin-6 is a member of the contactins, which mediate cell surface interactions during nervous system development. Contactin-6 has a key role in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. It is involved in oligodendrocytes generation by acting as a ligand of Notch1. It is also involved in motor coordination.
AdipoGen Lipocalin-2 rat rec
Protein. Rat lipocalin-2 aa 1-198 is fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. Lipocalin-2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development.
AdipoGen TNF-alpha Soluble h rec
Protein. A FLAG -tag is fused at the N-terminus of human TNF-alpha aa 85-223. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to human and mouse TNF-R1. Purity >95% SDS-PAGE. Tumor necrosis factor TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha MultimericTNF-alpha Prod. No. AG-40B-0019. Since the MultimericTNF-alpha mimics the membrane-bound form forms oligomers higher than trimer, it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha can be used.