Protein Resins
AdipoGen GPX3 human rec
Protein. Human GPX3 aa 21-226 is fused at the N-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS, pH7.2. Purity >90% SDS-PAGE. Glutathione peroxidase 3 GPX3 is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the diagnosis of clear cell type ovarian adenocarcinoma.
AdipoGen Progranulin rat rec
Protein. Signal peptide and rat progranulin aa 1-602 are fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >95% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
AdipoGen Jagged-1 msFc h rec
Protein. Signal peptide and extracellular domain of mouse Jagged-1 aa 1-1067 are fused at the C-terminus to the Fc portion of human IgG. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >90% SDS-PAGE. Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis in vitro. Defects in Jagged-1 are the cause of Alagille syndrome type 1 ALGS1 and tetralogy of Fallot TOF.
AdipoGen DLL1 humanFc human rec
Protein. Signal peptide and extracellular domain of human DLL1 aa 1-545 are fused at the C-terminus to the Fc portion of human IgG1. Source CHO cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Interacts with human Notch1 as confirmed by flow cytometry. Purity >90% SDS-PAGE. DLL1 Delta-like protein Delta1 is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
Revvity Health Sciences Inc AlphaScreen Omnibeads, 50,000 Assay Points
AlphaScreen Omnibeads, 50,000 Assay Points
Cayman Chemical WortmnInRapamycIn Conjugat 1mg
Consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker, which are released upon hydrolysis of the prodrug linker in vivo; inhibits the growth of tumors in mice better than rapamycin alone
AdipoGen POP1 human rec
Protein. Human POP1 aa 2-89 is fused at the N-terminus to a GST tag. Source E. coli. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin IL-1beta and IL-18. Members of the Nod-like receptor family NLRs, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 FCAS1, Muckle-Wells syndrome MWS and of chronic infantile neurologic cutaneous and articular syndrome CINCA. Pyrin domain-containing protein 1 POP1 interacts with the protein Asc Pycard and modulates the interaction of Asc to NLR proteins.
AdipoGen IGFLR1 hFc h rec
Protein. Human IGFLR1 aa 23-154 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.05EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Binds to its ligand IGFL3 human Prod. No. AG-40B-0090 http//www.adipogen.com/ag-40b-0090/igfl3-human-rec.html in the subnanomolar range < 1ng /ml. Purity >95% SDS-PAGE. Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans IGFL1 to 4 and one in mice mIGFL. mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 formerly TMEM-149. Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family.
AdipoGen DLK2 humanFc human rec
Protein. Signal peptide and the extracellular domain of human DLK2 aa 1-306 are fused at the C-terminus to the Fc portion of human IgG. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. DLK2 regulates adipogenesis.
ABclonal Technology Vitamin D Binding protein
The protein encoded by this gene belongs to the albumin gene family It is a multifunctional protein found in plasma ascitic fluid cerebrospinal fluid and on the surface of many cell types It binds to vitamin D and its plasma metabolites and transports them to target tissues Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Sigma Aldrich Fine Chemicals Biosciences Protein G Mag SepharoseR C
Protein G Mag Sepharose(R) are magnetic beads designed to simplify enrichment of target proteins by immunoprecipitation applications. Based on Sepharose(R) with Protein G as ligand. Protein G has high affinity for the fc region of IgG antibodies.